Refine your search
Collections
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Ranjan, R.
- Flubendiamide and Lead Exposure Alters Glial Fibrillary Acidic Protein and Aspartic Acid Concentrations in Cerebrospinal Fluid in Buffalo Calves
Abstract Views :381 |
PDF Views:0
Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
2 Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
2 Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 23, No 1 (2016), Pagination: 27-32Abstract
Changes in glial fibrillary acidic protein (GFAP) and aspartic acid (AA) concentrations in CSF following flubendiamide and lead exposure was studied. Male buffalo calves received daily oral dose of flubendiamide alone (n=4) @ 0.024mg/ kg/ day or lead acetate alone (n=4) @ 9.2 mg/ kg/ day or a combination of these two (n=4) for 90 days. Blood and CSF samples were collected and analyzed. GFAP in CSF did not alter in animals receiving flubendiamide alone. However, a significant increase in GFAP concentration in CSF was observed in animals receiving lead acetate. GFAP concentration showed a positive correlation (r = +0.545) with blood lead concentration in lead exposed animals, but no significant correlation was evident in animals exposed to both lead and flubendiamide. On the basis of results, it can be concluded that Aspartic acid concentration in CSF did not change significantly in lead treated animals, but increased significantly in flubendiamide treated animals. No significant alteration in AA level in CSF was observed in combined flubendiamide and lead treated animals. Flubendiamide exposure is associated with increase in AA level in CSF. Flubendiamide may have interactive effects with lead as evident from increase in GFAP and AA level in CSF after their combined exposure. This is the first report documenting alterations in GFAP and AA concentrations in CSF after flubendiamide exposure in mammals.Keywords
CSF, Heavy Metal, Pesticide, Toxicity.
References
- Miller GT, Sustaining the Earth. 6th ed. California: Thompson Learning Inc; 2004.
- Dondero F, Banni M, Negri A, Botti L, Dagnino A, Viarengo A. Interactions of a pesticide/ heavy metal mixture in marine bivalves: A trascriptomic assessment. BMC Genomics 2011;(12): 195; doi:10.1186/1471-2164-12-195.
- Lahm G, Cordova D, Barry JD. New and selective ryanodine receptor activators for insect control. Bioorganic Med Chem 2009; (17): 4127-33.
- Ranjan A, Dumka VK, Singh ND. Effect of flubendiamide, lead and their combined exposure on erythrocytic indices in water buffalo calves. B Environ Contam Toxicol 2014; (92): 410-4.
- Swarup D, Patra RC. Environmental pollution and its impact of domestic animals and wildlife. Indian J Anim Sci 2005; (75): 231-40.
- Krishnaswamy K, Kumar BD. Lead toxicity. Indian Pediatrics 1998; (35) 209-16.
- Bharathidhasani S, Kaur H, Mani V, Kewalramani N. Lead and cadmium contents of animal feed resources in Haryana. Indian J Anim Sci 2008; (78): 1268-72.
- Swarup D, Patra RC, Naresh R, Kumar P, Shekhar P. Blood lead levels in lactating cows reared around polluted localities: transfer of lead in to milk. Sci Total Environ 2005; (347): 106-10.
- Garza A, Vega R, Soto E. Cellular mechanisms of lead neurotoxicity. Med Sci Monit; 2006; (12): 57-65.
- ATSDR. Toxicological Profile of Lead. Atlanta, USA: Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services; 2007.
- Chen MH, Bullock R, Graham DI, Miller JD, Mc-Culloch J. Ischemic neuronal damage after acute subdural hematoma in the rat: effects of pretreatment with a glutamate antagonist. J Neurosurg 1991; (74): 944-50.
- Stover JF, Pleines UE, Morganti-Kossmann MC, Kossmann T, Lowitzsch K, Kempski OS. Neurotransmitters in cerebrospinal fluid reflect pathological activity. Eur J Clin Invest 1997; (27): 1038-43.
- Zhang H, Zhai SD, Li YM, Chen LR. Effect of different sample pretreatment methods on the concentrations of excitatory amino acids in cerebrospinal fluid determined by high-performance liquid chromatography. J Chromatogr B 2003; (784): 131-5.
- Radostits OM, Blood DC, Gay CC, Hinchcliff KW. Veterinary medicine: A textbook of diseases of cattle, sheep, pigs, goats and horses. 9thedn. London: W B Saunders; 2000.
- Sujatha K, Sriraman PK, Naidu NRG. Haematobiochemical alterations in lead toxicity in buffalo calves. Indian J Vet Pathol 2006; (30): 69-70.
- Chowdhury AR, Naha N. Heavy metal induced toxicity in male reproductive system. Indian J Toxicol 2002; (9): 61-7.
- Dwivedi SK, Swarup D, Dey S, Patra RC. Lead poisoning in cattle and buffalo near primary lead zinc smelter in India. Vet Human Toxicol 2001; (43): 93-4.
- Choubisa SL, Mishra GV, Sheikh Z, Bhardwaj B, Mali P, Jaroli VJ. Food, fluoride, and fluorosis in domestic ruminants in the Dungarpur district of Rajasthan, India. Fluoride 2011; (44): 70-6.
- Aurell A, Rosengren LE, Karlsson B, Olsson JE, Zbrnikova V, Haglid KG. Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction. Stroke 1991; (22): 1254-8.
- De-Armond SJ, Fajardo M, Naughton S.A. Degradation of glial fibrillary acidic protein by a calcium dependent proteinase: An electroblot study. Brain Res 1981; (262): 275-82.
- Struzynska L, Dabrowska-Bouta B, Koza K, Sulkowski G. Inflammation-like glial response in lead-exposed immature brain. Toxicol Sci 2007; (95): 156-62.
- Gong Z, Little AR, Jr-El-Fawal H, Evans HL. Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP). Ach Indust Hyg Toxicol 1995; (46): 381-90.
- Tiffany-Castiglioni E, Zmudzki J, Bratton GR. Cellular targets of lead toxicity: In vitro models. Toxicol 1986; (42): 305-15.
- Stoltenburg-Didinger G, Punder I, Peters B, Marcinkowski M, Herbst H, Winneke G, Wiegand H. Glial fibrillary acidic protein and RNA expression in adult rat hippocampus following low-level lead exposure during development. Histochem Cell Biol 1986; (105): 431-42.
- Griffin SWT, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, Roberts GW, Mrak RE. Glial-neuronal interactions in Alzheimer’s disease: The potential role of a ‘‘cytokine cycle’’ in disease progression. Brain Pathol 1998; (8): 65-72.
- Hong Z, Xinding Z, Tianlin Z, Liren C. Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries. Clinic Chem 2001; (47): 1458-62.
- Bullock R, Fujisawa H. The role of glutamate antagonists for the treatment of CNS injury. J Neurotrauma 1992; (9): S 443-62.
- Ince E, Karagol U, Deda G. Excitatory amino acid levels in cerebrospinal fluid of patients with infantile spasms. Acta Paediatrica 1997; (86): 1333-6.
- Araki K, Harada M, Ueda Y, Takino T, Kuriyama K. Alteration of amino acid content of cerebrospinal fluid from patients with epilepsy. Acta Neurol Scand 1988 (78): 473-9.
- Smith MO, George LW. Diseases of the Nervous System. In: Large Animal Internal Medicine, 4th Edn (Smith BP, Editor), Mosby, Elsevier, Missouri 2009.
- Improved Algorithm for Load Flow Analysis of Radial Distribution System
Abstract Views :185 |
PDF Views:0
Authors
Affiliations
1 Department of Electrical Engineering, UIET, MDU, Rohtak – 124001, Haryana, IN
2 Accenture Services Pvt. Ltd, Magrath Road – 560025, Bangalore, IN
3 IITB, Jhundpur, Sonipat – 131021, Haryana, IN
4 Department of Electrical Engineering, PDMCE, MDU, Bahadurgarh – 124507, Haryana, IN
1 Department of Electrical Engineering, UIET, MDU, Rohtak – 124001, Haryana, IN
2 Accenture Services Pvt. Ltd, Magrath Road – 560025, Bangalore, IN
3 IITB, Jhundpur, Sonipat – 131021, Haryana, IN
4 Department of Electrical Engineering, PDMCE, MDU, Bahadurgarh – 124507, Haryana, IN
Source
Indian Journal of Science and Technology, Vol 10, No 18 (2017), Pagination:Abstract
Objectives: In this paper an improved algorithm for load flow analysis of Radial Distribution Systems (RDS) is presented. The algorithm incorporates probabilistic variations of line and load data along with composite loads. Methodology: The algorithm uses Simple Backward and Forward Sweep based method for solving RDS and has further been modified to solve distribution systems with Distributed Generation (DG). Findings: This Improved algorithm for load flow analysis is tested on standard RDS and considerable promising results have been delivered for the system having Distributed Generator for improving the voltage profile and reduce the losses. Novelty/Improvement: The results obtained are exemplary that confirms usefulness of the algorithm and can have significant impact on future planning and operation purposes of unbalanced RDS.Keywords
Distributed Generations, Forward/Backward Sweep Algorithm, Load Flow Algorithm, Power Flow Analysis, Radial Distribution SystemsFull Text